Primary Cells Detail

Primary Cells: BBMVEC (B840-05)

Catalogue No.:	06090754
CAI No.:	B840-05
Cell Line Name:	BBMVEC (B840-05)
Species:	Bovine
Tissue:	Brain
Cell Line Description:	Bovine Brain Microvascular Endothelial Cells (BBMVEC) are isolated from microvessels of bovine brain. The cells are cryopreserved at second passage. BBMVEC can be cultured and propagated for at least 12 population doublings. Brain Microvascular Endothelial Cells form the basis of the blood-brain barrier, and have been used as a model for research on bacterial meningitis(1,2,3). Hypoxia-ischemia studies showed that BBMVEC cell death may exacerbate ischemic brain injury(4). BBMVEC have also been used to show oxyhemoglobin induces apoptosis in vascular endothelial cells(5). Co-culture with Atrocytes generate an in vitro model that closely mimics the in vivo situation for evaluating drug transport(6). References:1.Zysk, G. et al, Infect. Immun. 69(2):845-852 (2001) 2.Prasadarao, N.V. et al, Infect. Immun. 67(3):1131-1138(1999) 3.Wang, Y. et al, Infect. Immun. 67(9):4751-4756 (1999) 4.Zhang, J. et al, Brain Res. 877(2):134-140 (2000) 5.Meguro, T. et al, J. Neurochem. 77(4):1128-1135 6.Cecchelli, R. et al, Adv. Drug Deliv Rev 36:165 (1999) Characterization: Positive for DiI-Ac-LDL uptake. Animal tissues were USDA inspected
Subculture Routine:	Refer to data sheet
Culture Medium:	Bovine Brain Microvascular Endothelial Cell Growth Medium (B811-500) ECACC cat no. 06091526 Attachment Factor Solution (123-100) ECACC cat no. 07032109
Depositor:	Cell Applications Inc. (CAI), San Diego, USA
Originator:	Yes
Country:	USA
References:	None Specified By Depositor
Release Conditions:	No
Datasheet:	Click here

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