Custom Genetic Modification of Cell Lines
With our partners, InSCREENeX, ECACC offers custom genetically modified, mammalian cell systems for research and drug discovery.
The InSCREENeX SCREENflex™ technology creates stable transgenic cell lines in a third of the time of conventional recombinant techniques. More importantly, the SCREENflex™ cell systems are of unparalleled quality with regard to expression levels and stability of the transgene, enabling you to perform assays with the highest possible precision.
SCREENflex™ is a combination of specially designed SCREENflex™ master host cell lines optimized for transgene expression using a precise genetic modification step to introduce a “cassette”. Using molecular “cut and paste” this sequence is cleanly removed and replaced with a gene of interest. Unlike other similar technologies SCREENflex™ exchanges sequences it does not add them.
- Target genes are stably and consistently expressed
- No need for selection antibiotics
- Different master cell lines are available for different applications
- Cell line establishment within 1 month of receipt of a target cDNA sequence
- Available as seed vials or bulked as Frozen, Assay Ready reagent
A series of "Off the Shelf" G-protein coupled receptor (GPCR) cell lines generated using the SCREENflex™ technology are available to order.
For more information and quotations for customised cell line generation email hpacultures@hpa.org.uk or call us: +44 (0)1980 612512
